Web App Getting Slower the More it is Used

I have outsourced building a multi-client, multi-user web app to another firm who have built it in .NET on the Microsoft Azure platform.
We are currently experiencing a problem with page load speed. When you first open the web app the speed is fine, however with continued use, the pages suddenly become really slow (2mins to load a page!). You can ‘clear’ this problem by closing and reopening the browser (which is IE as currently the app only works on IE).

Any ideas? Could this be a caching related issue?

Thanks in advance.

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