How does it effect you personally? i tend to find that the more ‘tech’ based your site is, the more chance of people using adblock they’ll be. For instance, on one site i’m running i’m only getting 3 clicks per 600 visitors, which i think is really bad. Is that bad? i think my CTR is something like 60% 
Oops i meant to put my CTR is 0.59% now, not 60%
AdBlock will never affect your revenue - except if you use a pay per view model where their blocking the ads will save you money because you are not spending on ads views where the people will never buy anyway.