Thanks for the reply. The two major Lightbox's I know are Thickbox (jQuery based) and Lightbox 2.
Now, for Thickbox (http://jquery.com/demo/thickbox/), you're basically saying if I use it's code base I can just do the following (for a "single image") and it will just work:
<a href="images/single.jpg" title="This single image will pop out to a lightbox" class="thickbox"><img src="images/single_t.jpg" alt="Single Image"/></a>
Step two, the lightbox/imagemap.
I need to add the aforesaid area tags in the .js file? I just don't understand where. So, that's my main question. That's the problem I ran into with Lightbox 2 as well.
My next step would just be to move to Fancybox or ColorBox and try an entirely different method, but I was looking for recommendations on what others would do in such a case.