Are you doing search engine optimization for your website ? If yes then focus on targeting a specific country in which you want to promote your website, then make use of the country code TLD of your targeted country. This gives you better rankings in your preferred target location. However, if you do target several countries, using a country code TLD is not advisable; instead, use a generic TLD such as .com, .net, or .org which does not have any country associated with it. Also remember that search location can influence ranking results.