You can use position:sticky to fix the first column easy enough which is good for tables that are wide and you want to scroll sideways without losing the first column headers.
Here’s a very old example.
If you want to stick the first two columns then it gets a bit more complicated as you probably have to resort to fixed widths for those first two columns (or just the first column).
I’m not sure what use case there could be for other columns not scrolling sideways unless it was the last column perhaps.