I am sorry to say , no. CSS styles elements and individual characters aren't elements; they are one could say a 'property' of an element.
Besides, it really doesnt go with what CSS does. If all the letter Es are supposed to be red for some reason.. then that reason should be reflected in the markup. Otherwise that what Span is there for, specifically.. to HOOK CSS
Keep in mind tho , tho you aren't necessarily restricted to using SPAN. There are other presentational elements still around, such and I and B, which you could use to exclusively wrap a charter.