Server cache.. Ram full... cache clear required how plesk/linux

Basically server & Web page assets cache should turned off especially for hosting many sites at 1GB Ram cent os 6.5 vps server?
Can clear cache from Ram all from vps cent os / plesk vps without any impact to sites appearing?

I have cent os 6.5 vps Ram 2GB…but bandwidth is 3-9% percent low but Ram shows 1.25GB full … is it due to cache… can delete this cache to FREE RAM… ? SERVER REQUIRED RESTART FOR THIS?

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