It will be difficult to pull off a web layout like that. Things like the bubbles overlapping the content area is not very practical. And the background is very varied, meaning it won't tile well, which is the ideal. The sides of the content area aren't just shaded, but the curved-edge look requires more images, and the images would need to keep going to maintain the look. A lot of the content also requires images to make it look like that, but they are better avoided for content.
I don't mean this critically, but I think you'd better step back a bit, take a look at a lot of websites and see how they tend to use edge shadows etc. I would also recommend you step back to a simple wireframe with the content in place, then start building up a simple HTML/CSS template, starting with the content centered, then perhaps start adding a repeating background image, then a simple shadow effect down the sides etc.
The image you posted is fine for a Photoshop image but is not too practical for the web, I'm afraid. Websites are made up of separate bits of content that all flow together seamlessly (hopefully!), so you need to think in terms of individual components. Your image can't easily be broken p int separate bits.