What’s the best grid framework to use these days? 960.gs seems decent but isn’t that a bit small these days? At work we use a 1080 grid w/ responsive design.
1080.gs looks like it isn’t maintained. no examples…and no public code repo.
I am using “960+320”.
Its basically 960 but with extra 320 whenever someone’s browser window is larger then 1280.
Sometimes going with just 960.
Reason for that is that even on 30 inch monitor you dont want to be reading one meter of text from left to right.
The best grid to use is none at all. 
These grids are more trouble than they’re worth, IMHO. Personally, I prefer to establish the site’s needs, develop a wireframe and layout from that, and code from scratch. Then you don’t have a lot of unnecessary, confusing code that you didn’t write and that is hard to manipulate / debug. Just my 2c, anyhow.