I would doubt it. The volumes you described aren't particularly high.
But just to clarify: Are you worried about the sending ISP (that is, your ISP) considering it spam? If so, the simplest solution would be to talk to them. If you explain the situation, they should be able to advise.
Or are you are referring to the recipient's ISP? If so, that's likely to be less of an issue, given that many recipients will be receiving the messages via POP-3 mailboxes, or perhaps webmail, so the ISP doesn't enter the picture. But I can't think that's what you mean (correct me if I'm wrong).