speak for yourself
john resig's simple psuedo class... check
tibco pagebus 2.0... check
A book on design patterns and you are ready to rock. You can do some amazing things with prototype-based inheritance especially when you abstract a class-like inheritance methodology on top of it.
using .hasOwnProperty(), for(in) and _.each() gives you some amazing introspection that opens the world to your imagination and gives you a maintainable codebase to boot. The only downside is that you have some hard dependencies.