Glad you found it helpful!
The only thing I might do different would be to replace that <span> with a <big>. Just adjust the CSS according to the tag name.
Then I would add a <br> tag in the H2, those two changes would keep the highlights pointed out with CSS turned off.
That leaves you with the ability to still slip a generic span in there if needed for additional styling.
Think that <big>Big Business</big> runs America??<br>
<small>You might be interested to know that...</small>
<li>There are an estimated 29.6 million small businesses in the U.S.</li>
<li>Small Businesses employ roughly 50% of the private sector</li>
<li>Small Businesses represent 99.7% of all employer firms in the U.S.</li>
<p class="bold">The reality is that <big>Small Business</big> is the <b>heart-beat</b> of America!!</p>