Well, why don't you just try it and find out? 
Code:
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0
Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-
transitional.dtd">
<html xmlns="http://www.w3.org/1999/xhtml" dir="ltr"
lang="en-US">
<head>
<base
<title>OGS Nav</title>
<meta http-equiv="Content-Type" content="text/html;
charset=UTF-8" />
<style>
.a + .b + .c .cc{background:red;}
</style>
</head>
<body>
<div class="a">stuff</div>
<div class="b">stuff</div>
<div class="c">stuff<div class="cc">asdf</div></div>
</body>
</html>
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