I want to find a way of doing it that only affects the first letter of the first paragraph. Is there something simple I can tweak to get it working in Firefox? Does Firefox allow ":first-letter" elements on divs?
That's what you tried in the first place!
All4nerds other suggestion 
CSS
Code:
.big_letter:first-letter {
float:left;
color:#ffaa00;
font-size:50px; /* smacky no-no */
line-height:44px;
padding:2px 5px 0 0;
font-family: Futura, Times, Georgia;
}
Code:
<div id="entry">
<p class="big_letter">Bla bla bla</p>
<p>Bla bla bla</p>
<p>Bla bla bla</p>
</div>
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