Went for my daily O'Reilly ONLamp fix and found an interesting article on a Python-based Framework for Rapid Web Development called TurboGears. Think Ruby on Rails, Python style.
The 20 minute Wiki screencast shows some of the functionality and flexibility of the framework. Seeing as though I've never learned Ruby, and have always liked Python, I just might have to take this for a test drive.
You may also wanna try this one: http://www.djangoproject.com/
Great! I'll certainly give it a whirl.